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About the Sasaki Institute

Corporate philosophy

“We contribute to the advancement of medicine and health care through research for patients, along with relevant research support.”

Basic policy

The Sasaki Foundation is the medical research organization consisting of Sasaki Institute, Kyoundo Hospital, and Shonan Medical Examination Center. The three organizations cooperate closely with each other. We are committed to promoting our people’s health. To this end we are conducting the research and development of prevention, diagnosis, and treatment of cancer, among other diseases, attempting to advance medicine and human resources, and striving to promote and disseminate better medical care. The Institute carries out basic research, delivering the solutions through the experimental findings while the Hospital and the Medical Examination Center perform clinical research by taking advantage of clinical information. In case experimental results are required for the clinical research, they are given the opportunity for experiments in the Institute.

Non-profit activities

  1. Research on cancer and other diseases
  2. Therapeutic research devoted to the maintenance and improvement of patients’ quality of life
  3. Preventive medical research on cancer and other diseases
  4. Programs to train clinical investigators

Our efforts

We strive to move research forward from a perspective different than others, enhancing our position in the scientific community. Among the four non-profit activities, we are engaged in ’research on cancer and other diseases’ and ‘programs to train clinical investigators.’

We are doing the cancer research to substantiate ‘living with cancer.’ Cancer is a genetic disease. Given that mutations in DNA inevitably occur in our lifetime, it is quite hard to avoid developing cancer. After treatment, the regrowth of remaining cancer cells, cancer stem cells, and metastasized cancer cells all cause a big challenge. The time to cancer recurrence varies from several months to decades. One critical direction is to devise the therapeutic intervention strategies to reconcile with dormant cancer cells for escaping death from cancer by delaying the onset of cancer regrowth as long as possible. As for the diseases other than cancer, diabetes is one of the significant disorders with many unsolved problems, which will also be addressed by the experimental research.

Research organization

The Sasaki Institute is dedicated to the basic medical research on diseases, mainly cancer, with five departments built on distinct research disciplines: genome, metabolome, interactome, proteome, and phenome. Each department is comprised of a principle investigator as chief, two research scientists and one research assistant.

On the operation and management of public research expenditure

The Sasaki Foundation has implemented internal regulations “Regulations for the Handling of Public Research Expenditure” in accordance with the Guidelines for Management and Audit of Public Research Funds at Research Institutions stipulated by the Ministry of Education, Culture, Sports, Science and Technology effective as of February 15, 2007 (revised on February 18, 2014) and strived to properly use public research expenditure. In addition, we seek to prevent fraudulent behavior in research by enforcing internal regulations “Regulations for Responding to Misconduct in Research” in accordance with the Guidelines for Responding to Misconduct in Research by the Ministry on August 26, 2013.

Conforming to these regulations, a hotline is placed in the Compliance Office of the Foundation Secretariat to receive reports of misconduct in public research expenditure use and research activities, from both internal and external sources.
Contact e-mail address: compliance@po.kyoundo.jp

Organization/Member

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Director Takao Sekiya, Ph.D. CV Publications Link to The Japan Academy

Department of Cancer Genome Research

Chief (Principal Investigator) Hirofumi Nakaoka, Ph.D.
Research Scientist
Research Assistant
Collaborator

Department of Molecular Metabolic Regulation Research

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Chief (Principal Investigator)
Research Scientist
Research Assistant
Collaborator

Department of Cancer Cell Research

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Chief (Principal Investigator) Hideki Yamaguchi, Ph.D. Researchmap/Google Scholar
Research Scientist Yoshiko Nagano, Ph.D.
Research Scientist Makoto Miyazaki, Ph.D. Researchmap/Google Scholar
Research Assistant Yuko Nagamura
Collaborator Masako Yuki

Department of Peptidomics

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Chief (Principal Investigator) Kazuki Sasaki, M.D., Ph.D.
Research Scientist Masao Nakamura, Ph.D.
Research Assistant
Collaborator

Department of Phenome Research (Planned)

 

Office

Chief Takeyuki Sugiura, Ph.D.
Staff Nobuko Kimura

Research equipment

Imager
Imager
Microplate reader
Microplate reader
All-in-one fluorescent microscope
All-in-one fluorescent microscope
Molecular imager
Molecular imager
High-content screening platform
High-content screening platform
Real-time PCR detection system
Real-time PCR detection system
Desktop cell sorter
Desktop cell sorter
Chemiluminescence imaging system
Chemiluminescence imaging system
Cryostat
Cryostat
Zebrafish rearing device
Zebrafish rearing device
Time-lapse fluorescence microscope system
Time-lapse fluorescence microscope system
Table-top ultracentrifuge
Table-top ultracentrifuge
Floor type cooling centrifuge
Floor type cooling centrifuge
Ultrapure water system
Ultrapure water system
Micro-volume spectrophotometer
Micro-volume spectrophotometer

Historical timeline

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1882 June 1st Toyo Sasaki founds Kyoundo Hospital here in Kanda Surugadai, Tokyo.
1886 Masakichi Sasaki (the second Director of the Hospital) takes office as the Professor of Tokyo Imperial University Medical College (the first Japanese professor).
1894 Masakichi Sasaki builds a laboratory on his property and starts research on tuberculosis (the precursor of the later Sasaki Institute).
1896 Masakichi Sasaki assumes office as Director of Kyoundo Hospital and founds a tuberculosis sanitarium in Hiratsuka, Kanagawa.
1903 Jan Taking over from Masakichi and remodeling of the laboratory, Takaoki Sasaki (the third director of the Hospital) got engaged in research.
1913 Takaoki Sasaki takes office as Professor of Kyoto Imperial University College of Medical (Internal Medicine).
1915 Takaoki Sasaki assumes office as Director of Kyoundo Hospital and the Branch Hospital.
1923 Sep Both the Hospital and Institute are burn down in the Great Kanto Earthquake.
1924 May The institute resumes research in a temporary building.
ditto Takaoki Sasaki is awarded the Imperial Prize of the Japan Academy for “Studies on Bacterial Degradation of Protein and Constituent Amino Acids, and Synthesis of Amino Acids”.
1929 Reconstruction of the Hospital is completed.
1935 Feb Takaoki Sasaki and Tomizo Yoshida report on rat liver carcinogenesis by an azo dye in Virchow’s Archives.
ditto Takaoki Sasaki takes office as Director of Cancer Institute, Japanese Foundation for Cancer Research (concurrently).
1936 June Takaoki Sasaki and Tomizo Yoshida receive the Imperial Prize for “Experimental Production of Liver Carcinoma by Feeding with o-Amidoazotoluene“.
ditto Takaoki Sasaki is recommended as a Member of the German Academy.
1938 May The full-scale construction of the Institute is completed (at Surugadai 2-2).
1939 Jan The establishment of the foundation ‘Sasaki Institute’ is approved.
ditto Takaoki Sasaki becomes the first President and Director.
Takaoki Sasaki is recommended as a Member of the Imperial Academy.
1940 Nov Takaoki Sasaki is awarded the Order of Culture.
1941 Dec Takaoki Sasaki donates Kyoundo Hospital to the foundation ‘Sasaki Institute’.
1942 Takaoki Sasaki donates Hiratsuka Branch Hospital to the foundation ‘Sasaki Institute’
1950 The institute initiates the study of in-house established ascites hepatoma.
1951 Takaoki Sasaki is recommended as Person of Culture Merits. (the first person)
1953 Apr Tomizo Yoshida is inaugurated as the second Director of the Institute.
Nov Tomizo Yoshida is awarded the Imperial Prize again for “Pathological Studies on Yoshida Sarcoma”.
1954 Sep The Institute becomes a designated laboratory of the Japan Scholarship Foundation Law.
1959 Nov Tomizo Yoshida receives the Order of Culture.
1966 Oct The 9th International Cancer Congress is held in Tokyo, with Takaoki Sasaki as the honorary President and Tomizo Yoshida (Director of the Institute of that time) as the President.
Hirooki Sasaki becomes the second President of the Foundation.
1968 Jan The institute made an extension to the existing building.
1974 Apr Hirooki Sasaki becomes the third Director of the institute.
1988 The new hospital building is completed.
1990 June The chronicle ‘50 Year History of the Sasaki Institute’ is issued.
Sep The Institute building is completed. New research begins with three divisions (Departments of Pathology, Biochemistry and Cytogenetics) established.
ditto Motomichi Sasaki becomes the fourth Director.
1993 Shonan Medical Center opens.
1995 Oct Yoshiaki Hashimoto is inaugurated as the fifth Director.
1997 Sep Yoshiaki Hashimoto wins the Tomizo Yoshida Prize.
2001 Apr Yuji Kurokawa becomes the third President of the Foundation and also the sixth Director of the Institute, adopting the official name of the Sasaki Institute (affiliated to the Sasaki Foundation).
Oct Akihiko Maekawa is inaugurated as the seventh Director of the Institute.
2006 Apr Yuji Kurokawa is appointed the eighth Director of the Institute (concurrent President of the Foundation).
ditto Six research departments specialized for clinical research are implemented with respective chiefs and senior researchers appointed (all concurrently working at the Kyoundo Hospital or Shonan Medical Examination Center).
2010 Apr Takao Sekiya assumes the director position (ninth), newly establishing the Department of Cancer Genetics as the seventh division.
2012 Apr The Sasaki Foundation is authorized as a public interest incorporated foundation by the Cabinet Office.
2014 A call for donations for cancer research is launched.
2015 Dec Animal research facilities are reconstructed.
2017 Apr The institute is reorganized from 7 clinical research divisions to 5 basic research divisions, with Departments of Cancer Genome Research, Molecular Metabolic Regulation Research and Cancer Cell Research established.
2018 Aug The Department of Peptidomics is established.